According to State Police, the wreck happened around 8:30 near mile marker 63 in Woodford County.
They believe the drivers were trying to slow down as they approached the construction zone and crashed.
Troopers tell us one woman was flown to UK Hospital, where she is currently in serious condition.
They said two other men had to be taken to the hospital by ambulance.
According to KSP, the three drivers were traveling by themselves at the time of the crash.