Investigators said a pickup with four juvenile males inside drifted to the shoulder of the road, pulled a hard right and slammed into the back of a semi that was parked on the shoulder.
State Police said the collision happened around 5:30 p.m.
Investigators said one person was killed, another was airlifted to UK Hospital in Lexington, while two others were taken by ambulance to the same hospital.
All three accident victims were said to have serious injuries, according to investigators.
No names were released.